| Credit- Degree applicable | | Effective Quarter: Fall 2020 | I. Catalog Information
| BIOL 6B | Cell and Molecular Biology | 6 Unit(s) |
| | (See general education pages for the requirement this course meets.) Prerequisite: BIOL 6A or BIOL 6AH.
Advisory: EWRT 1A or EWRT 1AH or ESL 5; MATH 114 or equivalent. Lec Hrs: 48.00
Lab Hrs: 72.00
Out of Class Hrs: 96.00
Total Student Learning Hrs: 216.00 This course is an introduction to cellular structure and function, biological molecules, bioenergetics, molecular genetics, and cell proliferation. The laboratory includes extensive hands-on experimentation in molecular biology. |
| Student Learning Outcome Statements (SLO)
| | | Demonstrate the ability to use appropriate molecular biology techniques to answer research questions and to interpret and explain the results. |
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II. Course Objectives | A. | Describe basic themes in the study of cell biology. |
| B. | Explain the relationship between chemical properties and cell structures. |
| C. | Compare and contrast the structures of cells from various kingdoms. |
| D. | Investigate the structure and function of cell membranes. |
| E. | Compare and contrast energy-processing pathways in cells, including respiration, fermentation, and photosynthesis. |
| F. | Analyze critically the role the DNA technology plays in the advancement of biological knowledge. |
| G. | Explain the molecular mechanisms of gene expression. |
| H. | Investigate the effects of meiosis and recombination on genomes. |
| I. | Compare and contrast various modes of Mendelian and non-Mendelian genetics. |
| J. | Analyze critically the role that the molecular control of cell proliferation and differentiation plays in development and health. |
III. Essential Student Materials IV. Essential College Facilities | | Laboratory room with equipment for cellular and molecular biology (room SC2118 or equivalent) |
V. Expanded Description: Content and Form | A. | Describe basic themes in the study of cell biology. |
| 1. | The cell as the basic unit of life |
| 2. | Correlation of molecular and cellular structures with specific functions |
| 3. | Evolution: the inheritance and adaptive value of variations in molecular and cellular structures |
| B. | Explain the relationship between chemical properties and cell structures. |
| 1. | Atoms, molecules, and chemical bonds |
| C. | Compare and contrast the structures of cells from various kingdoms. |
| 1. | Prokaryotic and eukaryotic cells |
| D. | Investigate the structure and function of cell membranes. |
| 1. | Membrane structure: phospholipid bilayer and fluid mosaic |
| 2. | How things get into and out of cells |
| 3. | Diffusion, osmosis, and concentration gradients |
| 4. | Cell junctions and extracellular matrix |
| E. | Compare and contrast energy-processing pathways in cells, including respiration, fermentation, and photosynthesis. |
| 1. | Introduction to metabolism |
| F. | Analyze critically the role the DNA technology plays in the advancement of biological knowledge. |
| 1. | Binary fission in prokaryotes |
| 2. | Eukaryotic cell cycle and mitosis |
| G. | Explain the molecular mechanisms of gene expression. |
| 1. | DNA structure and function |
| 8. | Control of gene expression |
| H. | Investigate the effects of meiosis and recombination on genomes. |
| 1. | Sexual life cycles and recombination |
| 3. | Mechanisms that create genetic variation |
| I. | Compare and contrast various modes of Mendelian and non-Mendelian genetics. |
| 1. | Experimental genetics and Mendel's principles |
| J. | Analyze critically the role that the molecular control of cell proliferation and differentiation plays in development and health. |
| 1. | Polymerase chain reaction |
| 2. | Gene cloning and biotechnology |
VI. Assignments | A. | Readings from the text and other assigned sources |
| B. | Written laboratory reports, problem sets, or other assignments including results from laboratory experiments and critical analysis of data. |
VII. Methods of Instruction | | Lecture and visual aids
Discussion and problem solving performed in class
Quiz and examination review performed in class
Homework and extended projects
Collaborative learning and small group exercises
Collaborative projects
Laboratory experience which involve students in formal exercises of data collection and analysis
Laboratory discussion sessions and quizzes that evaluate the laboratory exercises
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VIII. Methods of Evaluating Objectives | A. | Lecture exams and quizzes, with both subjective and objective components, testing comprehension and requiring synthesis and application of course material. Evaluation based on percent correct and rubric. |
| B. | Lab exams and quizzes, including subjective, objective and practical components, covering experimental concepts and procedures. Evaluation based on percent correct and rubric. |
| C. | Lecture and laboratory finals requiring students to demonstrate the ability to summarize, integrate and critically analyze concepts examined throughout the course. Evaluation based on percent correct and rubric. |
| D. | Evaluation of lab reports or similar assignments demonstrating comprehension and application of the theoretical basis for experimental methods, and the correct analysis and interpretation of experimental results. |
IX. Texts and Supporting References | A. | Examples of Primary Texts and References |
| 1. | Urry, L.A., et al, "Campbell Biology," 11th ed. Menlo Park, CA: Pearson Education, 2017. |
| 2. | *Course syllabus and laboratory manual as prepared by instructor. |
| B. | Examples of Supporting Texts and References |
| 1. | Alberts, Bruce et al, "Molecular Biology of the Cell", 5th ed.. New York: Garland Science; 2007. |
| 2. | Berg, J.M. et al, "Biochemistry", 7th ed. New York: W.H. Freeman and Company; 2010. |
| 3. | Lodish, H. et al, "Molecular Cell Biology", 7th ed. New York: W.H. Freeman and Company; 2012. |
X. Lab Topics | A. | Protein Electrophoresis |
| C. | DNA restriction digests and electrophoresis |
| D. | Polymerase chain reaction |
| E. | Control of bacterial gene expression |
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